![]() ![]() ![]() gasseri, and the crystal structure was determined. ResultsĪ moonlighting protein, glycolytic glyceraldehyde 3-phosphate dehydrogenase (GAPDH), LGp40, that has multifunctional effects was purified from cultured L. Recombinant mutant component proteins were assayed, and their structures were superimposed to identify the detailed mechanism of alleviating allergic inflammation. Intrarectal inoculation of the active component-overexpressing Clear coli (lipopolysaccharide-free Escherichia coli) and intraperitoneal injection of recombinant component protein were used in a house dust mite (HDM)-induced allergic asthma mouse model to investigate the protective effect. The crystal structure of this component protein was determined using X-ray crystallography. The isolated component was subjected to in vitro functional assays and then cloned. gasseri were fractionated and screened for the active component for allergic asthma. Therefore, we aimed to isolate and investigate the immunomodulatory effect of the PPARγ activation component from L. Lactobacillus gasseri attenuates allergic airway inflammation through the activation of peroxisome proliferator- activated receptor γ (PPARγ) in dendritic cells. However, the probiotic components that interact with host target molecules and have a beneficial effect on allergic asthma remain unknown. The extra-intestinal effects of probiotics for preventing allergic diseases are well known. ![]()
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